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藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74189B2M-associated HLA-G/aAPC Cell

B2M-associated HLA-G/aAPC Cell
名稱 B2M-associated HLA-G/aAPC Cell
型號 CBP74189
報價
特點 B2M-associated HLA-G/aAPC Cell
  • 詳細(xì)內(nèi)容
I. Background
      HLA-G基因是一個功能性的非經(jīng)典I類HLA分子,具有經(jīng)典樣HLA抗原結(jié)構(gòu),位于染色體6p21.3的MHC區(qū),然而與經(jīng)典HLA-I類分子相比,HLA-G具有更少的多態(tài)性和更有限的組織分布。β2-微球蛋白(B2M)是細(xì)胞膜上組織相容性復(fù)合體(MHC,一組編碼人類白細(xì)胞表面抗原HLA基因群的通稱)輕鏈結(jié)構(gòu)的組成部分,在正常細(xì)胞新陳代謝過程中與MHC分離后釋放入血。β2-微球蛋白(B2M)分布于幾乎所有有核細(xì)胞(尤其在淋巴細(xì)胞和單核細(xì)胞存在豐富)和生物體液,包括血清、尿液和(關(guān)節(jié))滑液。
 
II. Introduction
Host Cell:N/A
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:90% FBS+10% DMSO
Culture Medium:F12K+10%FBS+3μg/ml Puromycin+600μg/ml Hygromycin B
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Functional(Report Gene) Assay
 
III. Representative Data

B2M-associated HLA-G/aAPC Cell

Figure 1. Recombinant B2M-associated HLA-G/aAPC Cell stably expressing B2M.

B2M-associated HLA-G/aAPC Cell

Figure 2. Recombinant B2M-associated HLA-G/aAPC Cell stably expressing HLA-G.

B2M-associated HLA-G/aAPC Cell

Figure 3. Dose Response of LILRB1 Blocking Antibody in LILRB1 Effector Reporter Cells (C13) with B2M-associated HLA-G/aAPC Cells (C15).

B2M-associated HLA-G/aAPC Cell

Figure 4.Dose Response of LILRB2 Blocking Antibody in LILRB2 Effector Reporter Cells (C24) with B2M-associated HLA-G/aAPC Cells(C15).

 


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